Optical Coherence Tomography and Subclinical Optical Neuritis in Longitudinally Extensive Transverse Myelitis

نویسندگان

  • Prakash Kumar Sinha
  • Deepika Joshi
  • Virendra Pratap Singh
  • Sujit Deshmukh
  • Usha Singh
  • Abhishek Pathak
  • Vijay Nath Mishra
  • Rameshwar Nath Chaurasia
  • Vivek Sharda
  • Garima Gupta
چکیده

Objective The aim is to compare the retinal nerve fiber layer (RNFL) thickness of longitudinally extensive transverse myelitis (LETM) eyes without previous optic neuritis with that of healthy control subjects. Methods Over 20 LETM eyes and 20 normal control eyes were included in the study and subjected to optical coherence tomography to evaluate and compare the RNFL thickness. Result Significant RNFL thinning was observed at 8 o'clock position in LETM eyes as compared to the control eyes (P = 0.038). No significant differences were seen in other RNFL measurements. Conclusion Even in the absence of previous optic neuritis LETM can lead to subclinical axonal damage leading to focal RNFL thinning.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Optical coherence tomography evaluation of retinal nerve fiber layer in longitudinally extensive transverse myelitis.

OBJECTIVE To compare optical coherence tomography (OCT) measurements on the retinal nerve fiber layer (RNFL) of healthy controls and patients with longitudinally extensive transverse myelitis (LETM) without previous optic neuritis. METHOD Twenty-six eyes from 26 patients with LETM and 26 control eyes were subjected to automated perimetry and OCT for comparison of RNFL measurements. RESULTS ...

متن کامل

Microstructural visual system changes in AQP4-antibody–seropositive NMOSD

OBJECTIVE To trace microstructural changes in patients with aquaporin-4 antibody (AQP4-ab)-seropositive neuromyelitis optica spectrum disorders (NMOSDs) by investigating the afferent visual system in patients without clinically overt visual symptoms or visual pathway lesions. METHODS Of 51 screened patients with NMOSD from a longitudinal observational cohort study, we compared 6 AQP4-ab-serop...

متن کامل

Enhancing Brain Lesions during Acute Optic Neuritis and/or Longitudinally Extensive Transverse Myelitis May Portend a Higher Relapse Rate in Neuromyelitis Optica Spectrum Disorders.

BACKGROUND AND PURPOSE Neuromyelitis optica spectrum disorders are inflammatory demyelinating disorders with optic neuritis and/or longitudinally extensive transverse myelitis episodes. We now know that neuromyelitis optica spectrum disorders are associated with antibodies to aquaporin-4, which are highly concentrated on astrocytic end-feet at the blood-brain barrier. Immune-mediated disruption...

متن کامل

Neuromyelitis optica spectrum disorder and Sjögren syndrome are overlapping disorders and participate in the same autoimmunity context?

Correspondence: Maria Lucia Vellutini Pimentel; Rua Garcia D’Avila, 64 sala 205; 22421-010 Rio de Janeiro RJ, Brasil; E-mail: [email protected] Conflict of interest: There is no conflict of interest to declare. Received 09 June 2014 Accepted 27 June 2014 Neuromyelitis optica (NMO), an idiopathic inflammatory demyelinating disease of the central nervous system that mainly affects the optic n...

متن کامل

Optical coherence tomography in neuromyelitis optica.

BACKGROUND Neuromyelitis optica (NMO) is an inflammatory disease with combined features of optic neuritis and myelitis. This pathologic entity may induce severe disability, including visual loss and paraplegia. Other than clinical follow-up, there is no marker for severity of the disease. OBJECTIVES To evaluate the use of optical coherence tomography (OCT) in NMO and to determine whether this...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 20  شماره 

صفحات  -

تاریخ انتشار 2017